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Y Combinator 257,879 views 1 month ago
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•Watch full video
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Intro
•
57:02 A Conversation with Demis Hassabis, Co-Founder and CEO of Google DeepMind Stanford Graduate School of Business 120K views • 11 days ago Live Playlist ()Mix (50+)47:40 Inside Anthropic, the $965 Billion AI Juggernaut | The Circuit Bloomberg Originals 1.3M views • 4 days ago Live Playlist ()Mix (50+)3:51 AI for forward thinking Businesses with a UK positioning overview and value drivers AiBizAssist 10 views • 7 days ago Live Playlist ()Mix (50+)41:30 How A Mathematician At Subway Revolutionized Number Theory Veritasium 173K views • 2 hours ago Live Playlist ()Mix (50+)31:26 State-Of-The-Art Prompting For AI Agents Y Combinator 339K views • 1 year ago Live Playlist ()Mix (50+)11:22 Demis Hassabis WARNS Us: "The 2027 Is Agent Explosion And AGI Inflection""AI Dispatched 5K views • 1 month ago Live Playlist ()Mix (50+)53:10 The arrival of AGI | Shane Legg (co-founder of DeepMind)Google DeepMind and Hannah Fry 1.2M views • 6 months ago Live Playlist ()Mix (50+)17:09 SpaceX: The IPO where the math doesn't matter | About That CBC News 344K views • 1 day ago Live Playlist ()Mix (50+)32:23 Demis Hassabis: Why AGI is Bigger than the Industrial Revolution & Where Are The Bottlenecks in AI 20VC with Harry Stebbings 387K views • 2 months ago Live Playlist ()Mix (50+)56:08 The future of intelligence | Demis Hassabis (Co-founder and CEO of DeepMind)Google DeepMind and Hannah Fry 10M views • 5 months ago Live Playlist ()Mix (50+)40:36 How SpaceX Humiliated Wall Street Patrick Boyle 694K views • 20 hours ago Live Playlist ()Mix (50+)26:52 Demis Hassabis: We're Three Quarters of the Way to AGI Sequoia Capital 238K views • 1 month ago Live Playlist ()Mix (50+)
Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough - YouTube
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Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
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Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
Y Combinator 257,879 views 1 month ago
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Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
Y Combinator
Y Combinator
2.28M subscribers
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257K views 1 month ago
257,879 views • Apr 29, 2026
Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistr…...more
...more
How this was made
Auto-dubbed
Audio tracks for some languages were automatically generated. Learn more
Chapters
View all
Intro ### Intro 0:00
Intro
0:00
Demis Hassabis: From Chess Prodigy to DeepMind ### Demis Hassabis: From Chess Prodigy to DeepMind 0:46
Demis Hassabis: From Chess Prodigy to DeepMind
0:46
What’s Missing Before We Get To AGI? ### What’s Missing Before We Get To AGI? 1:48
What’s Missing Before We Get To AGI?
1:48
Why Memory Is Still Unsolved ### Why Memory Is Still Unsolved 3:36
Why Memory Is Still Unsolved
3:36
How AlphaGo Shaped Gemini ### How AlphaGo Shaped Gemini 6:14
How AlphaGo Shaped Gemini
6:14
Why Smaller Models Are Getting So Powerful ### Why Smaller Models Are Getting So Powerful 8:06
Why Smaller Models Are Getting So Powerful
8:06
The 1000x Engineer ### The 1000x Engineer 10:46
The 1000x Engineer
10:46
Continual Learning and the Future of Agents ### Continual Learning and the Future of Agents 12:40
Continual Learning and the Future of Agents
12:40
People mentioned
1 person
Demis Hassabis #### British AI researcher (born 1976)
Transcript
Follow along using the transcript.
Show transcript
Y Combinator 2.28M subscribers
VideosAbout
Show less
Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
257,879 views 257K views
Apr 29, 2026
5K
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240 Comments
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@cyberdudecyber
1 month ago
Bro went from chess prodigy to game designer to neuroscientist to Nobel Prize winner to solve intelligence, create AGI, cure biology like a weekend to-do list. Some people really don’t know how to chill.
Show less Read more
Like
452
Dislike
❤ by @ycombinator
Reply
30 replies
Hide replies
30 replies
@StealthCoffeeMachine
1 month ago
I really like how Demis talks and explains subjects - it's not jargony, it's not over-selling anything. It is so "easy" to listen to, that you know this person understands their subject from top to bottom
Show less Read more
Like
30
Dislike
Reply
@bearonionlol
1 month ago
Demis is arguably the most influential person of this decade
Show less Read more
Like
143
Dislike
Reply
4 replies
Hide replies
4 replies
@thomasunise
1 month ago
Demis is easily one of the most import people in the world now Keep this man safe at all costs
Show less Read more
Like
83
Dislike
Reply
3 replies
Hide replies
3 replies
@KenScott-bg7qj
1 month ago
In Demis We Trust.
Show less Read more
Like
114
Dislike
Reply
2 replies
Hide replies
2 replies
@pedrodpadua
1 month ago
Demis Hasabis is my role model. If there is someone that I look up to, it’s him
Show less Read more
Like
24
Dislike
Reply
@johnk7025
1 month ago
demis ur the real agi
Show less Read more
Like
67
Dislike
Reply
2 replies
Hide replies
2 replies
@jeffhammerforteimpact
1 month ago
This is the kind of content that turns a 'viewer' into a 'member.' Proud to be part of the journey you’re building here.
Show less Read more
Like
6
Dislike
Reply
1 reply
Hide replies
1 reply
@MarkJones-f1t
1 month ago
“AQI doesn’t scale intelligence by burning more energy. It scales intelligence by removing the need for energy.”
Show less Read more
Like
16
Dislike
Reply
@amanmsiddiqui
1 month ago
We love Demis. Biggest takeaway from this talk: work on hard problems & AGI 2030.
Show less Read more
Like
29
Dislike
Reply
1 reply
Hide replies
1 reply
@DavidHolladay-e2r
1 month ago
Mr Hassabis is far and away the best thinker and least hype-master in the current AI domain.
Show less Read more
Like
11
Dislike
Reply
@thekollekta
1 month ago
I will never tire of hearing this man speak.
Show less Read more
Like
3
Dislike
Reply
@emauf
1 month ago
I love that he works to solve, not for ulterior motives. Boggles my mind how he escaped my attention in the past, He's a good soul. He re-assures me that there are people in AI who care about Safety and effects of extremities in developing a Pandora's box such as AI and AGI...
Show less Read more
Like
2
Dislike
Reply
@djg4653
1 month ago
Thanks for keeping us informed Demis
Show less Read more
Like
7
Dislike
Reply
@Hedgehogmustache
1 month ago
Narrator did a great job interviewing Demis!
Show less Read more
Like
3
Dislike
Reply
@krissn8111
1 month ago
Happy to hear Sir Demis Hassabis. He always deliver great insights if you listen to him.
Show less Read more
Like
5
Dislike
Reply
@danielatrotter3026
1 month ago
It’s impossible not to love Demis.
Show less Read more
Like
4
Dislike
Reply
1 reply
Hide replies
1 reply
@douglasalvaradocorrales
1 month ago
best 40:56 minutes of today, thanx for sharing
Show less Read more
Like
9
Dislike
Reply
@Sha-g8x2f
1 month ago
I see a Demis video I immediately watch it !!
Show less Read more
Like
3
Dislike
Reply
@YYLim-y1l
4 weeks ago
0:18 This is certainly divine lighting.
Show less Read more
Like
1
Dislike
Reply
NaN / NaN
Comments 240
Top Show featured commentsNewest Show recent comments, including potential spam
In this video
Timeline
Chapters
Transcript
Chapters
Intro ### Intro 0:00
Intro
0:00
Demis Hassabis: From Chess Prodigy to DeepMind ### Demis Hassabis: From Chess Prodigy to DeepMind 0:46
Demis Hassabis: From Chess Prodigy to DeepMind
0:46
What’s Missing Before We Get To AGI? ### What’s Missing Before We Get To AGI? 1:48
What’s Missing Before We Get To AGI?
1:48
Why Memory Is Still Unsolved ### Why Memory Is Still Unsolved 3:36
Why Memory Is Still Unsolved
3:36
How AlphaGo Shaped Gemini ### How AlphaGo Shaped Gemini 6:14
How AlphaGo Shaped Gemini
6:14
Why Smaller Models Are Getting So Powerful ### Why Smaller Models Are Getting So Powerful 8:06
Why Smaller Models Are Getting So Powerful
8:06
The 1000x Engineer ### The 1000x Engineer 10:46
The 1000x Engineer
10:46
Continual Learning and the Future of Agents ### Continual Learning and the Future of Agents 12:40
Continual Learning and the Future of Agents
12:40
Why AI Still Fails at Basic Reasoning ### Why AI Still Fails at Basic Reasoning 13:32
Why AI Still Fails at Basic Reasoning
13:32
Are Agents Overhyped or Just Getting Started? ### Are Agents Overhyped or Just Getting Started? 15:33
Are Agents Overhyped or Just Getting Started?
15:33
Can AI Become Truly Creative? ### Can AI Become Truly Creative? 18:31
Can AI Become Truly Creative?
18:31
Open Models, Gemma, and Local AI ### Open Models, Gemma, and Local AI 20:26
Open Models, Gemma, and Local AI
20:26
Why Gemini Was Built Multimodal ### Why Gemini Was Built Multimodal 22:26
Why Gemini Was Built Multimodal
22:26
What Happens When Inference Gets Cheap? ### What Happens When Inference Gets Cheap? 24:08
What Happens When Inference Gets Cheap?
24:08
From AlphaFold to the Virtual Cells ### From AlphaFold to the Virtual Cells 25:24
From AlphaFold to the Virtual Cells
25:24
AI as the Ultimate Tool for Science ### AI as the Ultimate Tool for Science 28:24
AI as the Ultimate Tool for Science
28:24
Advice for Founders ### Advice for Founders 30:43
Advice for Founders
30:43
The AlphaFold Breakthrough Pattern ### The AlphaFold Breakthrough Pattern 33:30
The AlphaFold Breakthrough Pattern
33:30
Can AI Make Real Scientific Discoveries? ### Can AI Make Real Scientific Discoveries? 35:20
Can AI Make Real Scientific Discoveries?
35:20
What to Build Before AGI Arrives ### What to Build Before AGI Arrives 37:59
What to Build Before AGI Arrives
37:59
Sync to video time
Description
Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
5K Likes
257,879 Views
Apr 29 2026
Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads Google DeepMind, pushing toward the same goal he set as a teenager: AGI. On this special live episode of How to Build the Future, he sat down with YC's Garry Tan to talk about what still needs to happen to get us to AGI, his advice for founders on how to stay ahead of the curve and what the next big scientific breakthroughs might be. Chapters: 00:00 — Intro 00:46 — Demis Hassabis: From Chess Prodigy to DeepMind 01:48 — What’s Missing Before We Get To AGI? 03:36 — Why Memory Is Still Unsolved 06:14 — How AlphaGo Shaped Gemini 08:06 — Why Smaller Models Are Getting So Powerful 10:46 — The 1000x Engineer 12:40 — Continual Learning and the Future of Agents 13:32 — Why AI Still Fails at Basic Reasoning 15:33 — Are Agents Overhyped or Just Getting Started? 18:31 — Can AI Become Truly Creative? 20:26 — Open Models, Gemma, and Local AI 22:26 — Why Gemini Was Built Multimodal 24:08 — What Happens When Inference Gets Cheap? 25:24 — From AlphaFold to the Virtual Cells 28:24 — AI as the Ultimate Tool for Science 30:43 — Advice for Founders 33:30 — The AlphaFold Breakthrough Pattern 35:20 — Can AI Make Real Scientific Discoveries? 37:59 — What to Build Before AGI Arrives Apply to Y Combinator: https://www.ycombinator.com/apply Work at a startup: https://www.ycombinator.com/jobs…...more
...more Show less
How this was made
Auto-dubbed
Audio tracks for some languages were automatically generated. Learn more
Chapters
View all
Intro ### Intro 0:00
Intro
0:00
Demis Hassabis: From Chess Prodigy to DeepMind ### Demis Hassabis: From Chess Prodigy to DeepMind 0:46
Demis Hassabis: From Chess Prodigy to DeepMind
0:46
What’s Missing Before We Get To AGI? ### What’s Missing Before We Get To AGI? 1:48
What’s Missing Before We Get To AGI?
1:48
Why Memory Is Still Unsolved ### Why Memory Is Still Unsolved 3:36
Why Memory Is Still Unsolved
3:36
People mentioned
1 person
Demis Hassabis #### British AI researcher (born 1976)
Transcript
Follow along using the transcript.
Show transcript
Y Combinator 2.28M subscribers
VideosAbout
Transcript
57:02
A Conversation with Demis Hassabis, Co-Founder and CEO of Google DeepMind
Stanford Graduate School of Business
120K views • 11 days ago
47:40
Inside Anthropic, the $965 Billion AI Juggernaut | The Circuit
Bloomberg Originals
1.3M views • 4 days ago
New
3:51
AI for forward thinking Businesses with a UK positioning overview and value drivers
AiBizAssist
10 views • 7 days ago
41:30
How A Mathematician At Subway Revolutionized Number Theory
Veritasium
173K views • 2 hours ago
New
31:26
State-Of-The-Art Prompting For AI Agents
Y Combinator
339K views • 1 year ago
11:22
Demis Hassabis WARNS Us: "The 2027 Is Agent Explosion And AGI Inflection""
AI Dispatched
5K views • 1 month ago
53:10
The arrival of AGI | Shane Legg (co-founder of DeepMind)
Google DeepMind and Hannah Fry
1.2M views • 6 months ago
17:09
SpaceX: The IPO where the math doesn't matter | About That
CBC News
344K views • 1 day ago
New
32:23
Demis Hassabis: Why AGI is Bigger than the Industrial Revolution & Where Are The Bottlenecks in AI
20VC with Harry Stebbings
387K views • 2 months ago
56:08
The future of intelligence | Demis Hassabis (Co-founder and CEO of DeepMind)
Google DeepMind and Hannah Fry
10M views • 5 months ago
40:36
How SpaceX Humiliated Wall Street
Patrick Boyle
694K views • 20 hours ago
New
26:52
Demis Hassabis: We're Three Quarters of the Way to AGI
Sequoia Capital
238K views • 1 month ago
31:48
Inside Google DeepMind: AGI, Robotics, & World Models Explained - Demis Hassabis
All-In Podcast
599K views • 9 months ago
41:21
NVIDIA's Jensen Huang on Building the Dynamo of the Intelligence Age
Sequoia Capital
151K views • 4 days ago
New
31:12
FULL DISCUSSION: Google's Demis Hassabis, Anthropic's Dario Amodei Debate the World After AGI | AI1G
DRM News
996K views • 4 months ago
11:55
Why the US Is Investing in Quantum Computing
Bloomberg Television
93K views • 1 day ago
New
29:02
Nobel Prize lecture: Demis Hassabis, Nobel Prize in Chemistry 2024
Nobel Prize
193K views • 1 year ago
53:21
The Future Of Brain-Computer Interfaces
Y Combinator
255K views • 3 months ago
42:48
A new era of discovery: AI and the frontiers of science with Demis Hassabis
Google for Developers
37K views • 3 weeks ago
50:11
Inside Claude Code With Its Creator Boris Cherny
Y Combinator
224K views • 3 months ago
Show more
•
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0:00
")
0:00 / 0:00
Live
•Watch full video
•
Intro
•
57:02 A Conversation with Demis Hassabis, Co-Founder and CEO of Google DeepMind Stanford Graduate School of Business 120K views • 11 days ago Live Playlist ()Mix (50+)47:40 Inside Anthropic, the $965 Billion AI Juggernaut | The Circuit Bloomberg Originals 1.3M views • 4 days ago Live Playlist ()Mix (50+)3:51 AI for forward thinking Businesses with a UK positioning overview and value drivers AiBizAssist 10 views • 7 days ago Live Playlist ()Mix (50+)41:30 How A Mathematician At Subway Revolutionized Number Theory Veritasium 173K views • 2 hours ago Live Playlist ()Mix (50+)31:26 State-Of-The-Art Prompting For AI Agents Y Combinator 339K views • 1 year ago Live Playlist ()Mix (50+)11:22 Demis Hassabis WARNS Us: "The 2027 Is Agent Explosion And AGI Inflection""AI Dispatched 5K views • 1 month ago Live Playlist ()Mix (50+)53:10 The arrival of AGI | Shane Legg (co-founder of DeepMind)Google DeepMind and Hannah Fry 1.2M views • 6 months ago Live Playlist ()Mix (50+)17:09 SpaceX: The IPO where the math doesn't matter | About That CBC News 344K views • 1 day ago Live Playlist ()Mix (50+)32:23 Demis Hassabis: Why AGI is Bigger than the Industrial Revolution & Where Are The Bottlenecks in AI 20VC with Harry Stebbings 387K views • 2 months ago Live Playlist ()Mix (50+)56:08 The future of intelligence | Demis Hassabis (Co-founder and CEO of DeepMind)Google DeepMind and Hannah Fry 10M views • 5 months ago Live Playlist ()Mix (50+)40:36 How SpaceX Humiliated Wall Street Patrick Boyle 694K views • 20 hours ago Live Playlist ()Mix (50+)26:52 Demis Hassabis: We're Three Quarters of the Way to AGI Sequoia Capital 238K views • 1 month ago Live Playlist ()Mix (50+)
Sign in to confirm you’re not a bot This helps protect our community. Learn more
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Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
Y Combinator
Y Combinator
2.28M subscribers
Subscribe
Subscribed
5K
Save
Download
Download
257K views 1 month ago
257,879 views • Apr 29, 2026
Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistr…...more
...more
How this was made
Auto-dubbed
Audio tracks for some languages were automatically generated. Learn more
Chapters
View all
Intro ### Intro 0:00
Intro
0:00
Demis Hassabis: From Chess Prodigy to DeepMind ### Demis Hassabis: From Chess Prodigy to DeepMind 0:46
Demis Hassabis: From Chess Prodigy to DeepMind
0:46
What’s Missing Before We Get To AGI? ### What’s Missing Before We Get To AGI? 1:48
What’s Missing Before We Get To AGI?
1:48
Why Memory Is Still Unsolved ### Why Memory Is Still Unsolved 3:36
Why Memory Is Still Unsolved
3:36
How AlphaGo Shaped Gemini ### How AlphaGo Shaped Gemini 6:14
How AlphaGo Shaped Gemini
6:14
Why Smaller Models Are Getting So Powerful ### Why Smaller Models Are Getting So Powerful 8:06
Why Smaller Models Are Getting So Powerful
8:06
The 1000x Engineer ### The 1000x Engineer 10:46
The 1000x Engineer
10:46
Continual Learning and the Future of Agents ### Continual Learning and the Future of Agents 12:40
Continual Learning and the Future of Agents
12:40
People mentioned
1 person
Demis Hassabis #### British AI researcher (born 1976)
Transcript
Follow along using the transcript.
Show transcript
Y Combinator 2.28M subscribers
VideosAbout
Show less
Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
257,879 views 257K views
Apr 29, 2026
5K
Save
Download
Download
240 Comments
Sort comments
Sort by
Top Show featured commentsNewest Show recent comments, including potential spam
Add a comment...
@cyberdudecyber
1 month ago
Bro went from chess prodigy to game designer to neuroscientist to Nobel Prize winner to solve intelligence, create AGI, cure biology like a weekend to-do list. Some people really don’t know how to chill.
Show less Read more
Like
452
Dislike
❤ by @ycombinator
Reply
30 replies
Hide replies
30 replies
@StealthCoffeeMachine
1 month ago
I really like how Demis talks and explains subjects - it's not jargony, it's not over-selling anything. It is so "easy" to listen to, that you know this person understands their subject from top to bottom
Show less Read more
Like
30
Dislike
Reply
@bearonionlol
1 month ago
Demis is arguably the most influential person of this decade
Show less Read more
Like
143
Dislike
Reply
4 replies
Hide replies
4 replies
@thomasunise
1 month ago
Demis is easily one of the most import people in the world now Keep this man safe at all costs
Show less Read more
Like
83
Dislike
Reply
3 replies
Hide replies
3 replies
@KenScott-bg7qj
1 month ago
In Demis We Trust.
Show less Read more
Like
114
Dislike
Reply
2 replies
Hide replies
2 replies
@pedrodpadua
1 month ago
Demis Hasabis is my role model. If there is someone that I look up to, it’s him
Show less Read more
Like
24
Dislike
Reply
@johnk7025
1 month ago
demis ur the real agi
Show less Read more
Like
67
Dislike
Reply
2 replies
Hide replies
2 replies
@jeffhammerforteimpact
1 month ago
This is the kind of content that turns a 'viewer' into a 'member.' Proud to be part of the journey you’re building here.
Show less Read more
Like
6
Dislike
Reply
1 reply
Hide replies
1 reply
@MarkJones-f1t
1 month ago
“AQI doesn’t scale intelligence by burning more energy. It scales intelligence by removing the need for energy.”
Show less Read more
Like
16
Dislike
Reply
@amanmsiddiqui
1 month ago
We love Demis. Biggest takeaway from this talk: work on hard problems & AGI 2030.
Show less Read more
Like
29
Dislike
Reply
1 reply
Hide replies
1 reply
@DavidHolladay-e2r
1 month ago
Mr Hassabis is far and away the best thinker and least hype-master in the current AI domain.
Show less Read more
Like
11
Dislike
Reply
@thekollekta
1 month ago
I will never tire of hearing this man speak.
Show less Read more
Like
3
Dislike
Reply
@emauf
1 month ago
I love that he works to solve, not for ulterior motives. Boggles my mind how he escaped my attention in the past, He's a good soul. He re-assures me that there are people in AI who care about Safety and effects of extremities in developing a Pandora's box such as AI and AGI...
Show less Read more
Like
2
Dislike
Reply
@djg4653
1 month ago
Thanks for keeping us informed Demis
Show less Read more
Like
7
Dislike
Reply
@Hedgehogmustache
1 month ago
Narrator did a great job interviewing Demis!
Show less Read more
Like
3
Dislike
Reply
@krissn8111
1 month ago
Happy to hear Sir Demis Hassabis. He always deliver great insights if you listen to him.
Show less Read more
Like
5
Dislike
Reply
@danielatrotter3026
1 month ago
It’s impossible not to love Demis.
Show less Read more
Like
4
Dislike
Reply
1 reply
Hide replies
1 reply
@douglasalvaradocorrales
1 month ago
best 40:56 minutes of today, thanx for sharing
Show less Read more
Like
9
Dislike
Reply
@Sha-g8x2f
1 month ago
I see a Demis video I immediately watch it !!
Show less Read more
Like
3
Dislike
Reply
@YYLim-y1l
4 weeks ago
0:18 This is certainly divine lighting.
Show less Read more
Like
1
Dislike
Reply
NaN / NaN
Comments 240
Top Show featured commentsNewest Show recent comments, including potential spam
In this video
Timeline
Chapters
Transcript
Chapters
Intro ### Intro 0:00
Intro
0:00
Demis Hassabis: From Chess Prodigy to DeepMind ### Demis Hassabis: From Chess Prodigy to DeepMind 0:46
Demis Hassabis: From Chess Prodigy to DeepMind
0:46
What’s Missing Before We Get To AGI? ### What’s Missing Before We Get To AGI? 1:48
What’s Missing Before We Get To AGI?
1:48
Why Memory Is Still Unsolved ### Why Memory Is Still Unsolved 3:36
Why Memory Is Still Unsolved
3:36
How AlphaGo Shaped Gemini ### How AlphaGo Shaped Gemini 6:14
How AlphaGo Shaped Gemini
6:14
Why Smaller Models Are Getting So Powerful ### Why Smaller Models Are Getting So Powerful 8:06
Why Smaller Models Are Getting So Powerful
8:06
The 1000x Engineer ### The 1000x Engineer 10:46
The 1000x Engineer
10:46
Continual Learning and the Future of Agents ### Continual Learning and the Future of Agents 12:40
Continual Learning and the Future of Agents
12:40
Why AI Still Fails at Basic Reasoning ### Why AI Still Fails at Basic Reasoning 13:32
Why AI Still Fails at Basic Reasoning
13:32
Are Agents Overhyped or Just Getting Started? ### Are Agents Overhyped or Just Getting Started? 15:33
Are Agents Overhyped or Just Getting Started?
15:33
Can AI Become Truly Creative? ### Can AI Become Truly Creative? 18:31
Can AI Become Truly Creative?
18:31
Open Models, Gemma, and Local AI ### Open Models, Gemma, and Local AI 20:26
Open Models, Gemma, and Local AI
20:26
Why Gemini Was Built Multimodal ### Why Gemini Was Built Multimodal 22:26
Why Gemini Was Built Multimodal
22:26
What Happens When Inference Gets Cheap? ### What Happens When Inference Gets Cheap? 24:08
What Happens When Inference Gets Cheap?
24:08
From AlphaFold to the Virtual Cells ### From AlphaFold to the Virtual Cells 25:24
From AlphaFold to the Virtual Cells
25:24
AI as the Ultimate Tool for Science ### AI as the Ultimate Tool for Science 28:24
AI as the Ultimate Tool for Science
28:24
Advice for Founders ### Advice for Founders 30:43
Advice for Founders
30:43
The AlphaFold Breakthrough Pattern ### The AlphaFold Breakthrough Pattern 33:30
The AlphaFold Breakthrough Pattern
33:30
Can AI Make Real Scientific Discoveries? ### Can AI Make Real Scientific Discoveries? 35:20
Can AI Make Real Scientific Discoveries?
35:20
What to Build Before AGI Arrives ### What to Build Before AGI Arrives 37:59
What to Build Before AGI Arrives
37:59
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Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
5K Likes
257,879 Views
Apr 29 2026
Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads Google DeepMind, pushing toward the same goal he set as a teenager: AGI. On this special live episode of How to Build the Future, he sat down with YC's Garry Tan to talk about what still needs to happen to get us to AGI, his advice for founders on how to stay ahead of the curve and what the next big scientific breakthroughs might be. Chapters: 00:00 — Intro 00:46 — Demis Hassabis: From Chess Prodigy to DeepMind 01:48 — What’s Missing Before We Get To AGI? 03:36 — Why Memory Is Still Unsolved 06:14 — How AlphaGo Shaped Gemini 08:06 — Why Smaller Models Are Getting So Powerful 10:46 — The 1000x Engineer 12:40 — Continual Learning and the Future of Agents 13:32 — Why AI Still Fails at Basic Reasoning 15:33 — Are Agents Overhyped or Just Getting Started? 18:31 — Can AI Become Truly Creative? 20:26 — Open Models, Gemma, and Local AI 22:26 — Why Gemini Was Built Multimodal 24:08 — What Happens When Inference Gets Cheap? 25:24 — From AlphaFold to the Virtual Cells 28:24 — AI as the Ultimate Tool for Science 30:43 — Advice for Founders 33:30 — The AlphaFold Breakthrough Pattern 35:20 — Can AI Make Real Scientific Discoveries? 37:59 — What to Build Before AGI Arrives Apply to Y Combinator: https://www.ycombinator.com/apply Work at a startup: https://www.ycombinator.com/jobs…...more
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Chapters
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Intro ### Intro 0:00
Intro
0:00
Demis Hassabis: From Chess Prodigy to DeepMind ### Demis Hassabis: From Chess Prodigy to DeepMind 0:46
Demis Hassabis: From Chess Prodigy to DeepMind
0:46
What’s Missing Before We Get To AGI? ### What’s Missing Before We Get To AGI? 1:48
What’s Missing Before We Get To AGI?
1:48
Why Memory Is Still Unsolved ### Why Memory Is Still Unsolved 3:36
Why Memory Is Still Unsolved
3:36
People mentioned
1 person
Demis Hassabis #### British AI researcher (born 1976)
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