# FlowLet：基于小波流匹配的条件3D脑MRI合成

- 来源：HuggingFace Daily Papers（社区热门论文）
- 发布时间：2026-06-08 08:00
- AIHOT 分数：54
- AIHOT 链接：https://aihot.virxact.com/items/cmq9bsmkd0ag3slldsvow6pp1
- 原文链接：https://arxiv.org/abs/2601.05212

## AI 摘要

FlowLet是一种条件生成框架，在可逆3D小波域中利用流匹配合成年龄条件的3D脑MRI，避免潜在压缩伪影并降低计算开销。实验表明，仅需少量采样步即可生成高保真体积；用其数据训练脑年龄预测模型可改善欠代表性年龄组的表现，区域分析证实解剖结构得以保留。

## 正文

Brain Magnetic Resonance Imaging (MRI) plays a central role in studying neurological development, aging, and diseases. One key application is Brain Age Prediction (BAP), which estimates an individual's biological brain age from MRI data. Effective BAP models require large, diverse, and age-balanced datasets, whereas existing 3D MRI datasets are demographically skewed, limiting fairness and generalizability. Acquiring new data is costly and ethically constrained, motivating generative data augmentation. Current generative methods are often based on latent diffusion models, which operate in learned low dimensional latent spaces to address the memory demands of volumetric MRI data. However, these methods are typically slow at inference, may introduce artifacts due to latent compression, and are rarely conditioned on age, thereby affecting the BAP performance. In this work, we propose FlowLet, a conditional generative framework that synthesizes age-conditioned 3D MRIs by leveraging flow matching within an invertible 3D wavelet domain, helping to avoid reconstruction artifacts and reducing computational demands. Experiments show that FlowLet generates high-fidelity volumes with few sampling steps. Training BAP models with data generated by FlowLet improves performance for underrepresented age groups, and region-based analysis confirms preservation of anatomical structures.