TRIAGE:基于LLM辩证推理的不规则医疗时间序列可解释风险预测
阅读原文· arxiv.org针对电子健康记录中不规则采样的医疗时间序列(ISMTS),LLM在临床早期预警中常将分级风险压缩为过度自信的二分类预测,导致校准失效。TRIAGE框架通过训练LLM生成对抗性临床结局的辩证推理,产出连续风险评分并附带可验证的临床依据。在三个ISMTS基准上,TRIAGE平均AUPRC提升3.3%,校准误差降低81%;LLM-as-a-judge评估显示其推理质量较基线提升20%。源代码已开源。
Clinical early warning systems built on electronic health records, in which clinical observations are recorded as irregularly sampled medical time series (ISMTS), must deliver both calibrated risk scores for patient triage and interpretable rationales that clinicians can verify. Large Language Models (LLMs) have been explored for this task, yet they collapse graded clinical risk into overconfident binary predictions. This risk polarization undermines both calibration and cross-patient comparability. To address this, we propose TRIAGE, a framework that trains an LLM to generate dialectical reasoning over competing clinical outcomes by eliciting outcome-specific rationales. This dialectical formulation mitigates risk polarization, enabling a single LLM to yield continuous risk scores grounded in explicit clinical reasoning. Evaluated on three ISMTS benchmarks, TRIAGE achieves an average AUPRC improvement of 3.3% and reduces calibration error by 81% compared to the competitive baselines. An LLM-as-a-judge assessment further shows that our rationales surpass post-hoc explanations from the baseline by 20% in clinical reasoning quality. The source code is available at https://github.com/HyeongWon-Jang/TRIAGE .