BioInsight:面向交互式生物医学知识发现的多智能体编排
阅读原文· arxiv.orgBioInsight 是一个多智能体系统,将静态生物医学报告生成转变为交互式、以证据为中心的界面生成。给定疾病名称、蛋白质关联表和可选队列元数据,系统通过类型化中间产物(排名通路、文献证据包、蛋白质级推理笔记、引用报告、仪表盘模式和交互界面)组织疾病特异性证据。它将证据检索与机制推理分离,通过确定性组件规范化引用,并将报告中的结构化证据转换为交互界面。在标准化生物医学问答、蛋白质功能推理和端到端证据综合评测中,BioInsight达到最佳性能,表明生物医学AI系统应转向保留来源的交互式证据制品。
Biomedical researchers increasingly use AI-generated analyses and reports to interpret protein-level signals, but static outputs are often insufficient for research decision-making, where users need to inspect evidence, assess uncertainty, compare mechanisms, and refine hypotheses. We present BioInsight, a multi-agent system that moves from static biomedical report generation to interactive evidence-centered interactive interface generation. Given a disease name, a protein association table, and optional cohort metadata, BioInsight organizes disease-specific evidence through typed intermediate artifacts, including ranked pathways, literature evidence packets, protein-level reasoning notes, citation-grounded reports, dashboard schemas, and rendered interactive interfaces. The system decomposes evidence retrieval from mechanistic reasoning, normalizes citations through deterministic components, and converts the same structured evidence used in the report into an interactive interface. We evaluate BioInsight on standardized biomedical QA, challenging protein-function reasoning, and end-to-end biomedical evidence synthesis. Results show that BioInsight achieves best, and suggest that biomedical AI systems should move beyond text-only and static reports toward provenance-preserving, interactive evidence artifacts.